Endogenous hyperinsulinemic hypoglycemia as a case report: noninsulinoma pancreatogenic hypoglycemia syndrome (NIPHS)

Authors

  • María Fernández-Riesgo Internal Medicine Department, Marina Baixa Hospital, Villajollosa, Alicante, Spain https://orcid.org/0000-0003-0026-8245
  • Javier Ena Internal Medicine Department, Marina Baixa Hospital, Villajollosa, Alicante, Spain
  • Isabel Sellés Internal Medicine Department, Marina Baixa Hospital, Villajollosa, Alicante, Spain
  • Roberto Abellán-Ponce Internal Medicine Department, Marina Baixa Hospital, Villajollosa, Alicante, Spain
  • José Ramón Domínguez-Escribano Department of Endocrinology and Nutrition, San Juan de Alicante University Hospital, Alicante, Spain

DOI:

https://doi.org/10.32818/reccmi.a9n2a13

Keywords:

hyperinsulinism, hypoglycemia, pancreatogenous

Abstract

Endogenous hyperinsulinemic hypoglycemia in non-diabetic people is a cause to take into account in nondiabetic patients with hypoglycemia. Its interest lies in its low incidence and the importance of recognizing its
diagnosis and treatment. We present the case of a 40-year-old woman with frequent episodes of hypoglycemia
whose definitive diagnosis was non-insulinoma pancreatogenous hypoglycemia using the oral glucose overload test, which showed abnormally high insulin and C-peptide values in relation to capillary blood glucose. In
our case, the resolution of the symptoms took place with medical treatment (lanreotide).

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Iqbal F, Witczak J. Noninsulinoma pancreatogenous hypoglycemia syndrome (NIPHS) – a therapeutic challenge. Endocrine Abstracts. 2022; 82: 5. https://doi.org/10.1530/endoabs.82.p5 (último acceso jul. 2024). DOI: https://doi.org/10.1530/endoabs.82.P5

Ng CL. Hypoglycaemia in nondiabetic patients – an evidence based ap¬proach. Aust Fam Physician. 2010; 39(6): 399-404. Accesible en: https:// www.racgp.org.au/getattachment/e5311638-b32d-4a11-88b3-9a35e¬e268d83/Hypoglycaemia-in-nondiabetic-patients-an-evidence.aspx. (últi¬mo acceso jul. 2024).

Davi MV, Pia A, Guarnotta V, Pizza G, Colao A, Faggiano A; NIKE Group. The treatment of hyperinsulinemic hypoglycaemia in adults: an update. J En¬docrinol Invest. 2017; 40(1): 9-20. doi: https://doi.org/10.1007/s40618-016- 0536-3 (último acceso jul. 2024). DOI: https://doi.org/10.1007/s40618-016-0536-3

De Leon DD, Arnoux JB, Banerjee I, Bergadá I, Bhatti T, Conwell LS, et al. Inter¬national Guidelines for the Diagnosis and Management of Hyperinsulinism. Horm Res Paediatr. 2023. doi: https://doi.org/10.1159/000531766 (último acceso jul. 2024). DOI: https://doi.org/10.1159/000531766

Cryer PE, Axelrod L, Grossman AB, Heller SR, Montori VM, Seaquist ER, Servi¬ce FJ. Endocrine Society. Evaluation and management of adult hypoglyce¬mic disorders: an Endocrine Society Clinical Practice Guideline. J Clin Endo¬crinol Metab. 2009; 94(3): 709-28. doi: https://doi.org/10.1210/jc.2008-1410 (último acceso jul. 2024). DOI: https://doi.org/10.1210/jc.2008-1410

Anderson B, Nostedt J, Girgis S, Dixon T, Agrawal V, Wiebe E, et al. Insulinoma or non-insulinoma pancreatogenous hypoglycemia? A diagnostic dilem¬ma. J Surg Case Rep. 2016; 2016(11): rjw188. doi: https://doi.org/10.1093/ jscr/rjw188 (último acceso jul. 2024). DOI: https://doi.org/10.1093/jscr/rjw188

Anlauf M, Wieben D, Perren A, Sipos B, Komminoth P, Raffel A, et al. Persis¬tent hyperinsulinemic hypoglycemia in 15 adults with diffuse nesidioblas¬tosis: diagnostic criteria, incidence, and characterization of beta-cell chan¬ges. Am J Surg Pathol. 2005; 29(4): 524-533. doi: https://doi.org/10.1097/01. pas.0000151617.14598.ae (último acceso jul. 2024). DOI: https://doi.org/10.1097/01.pas.0000151617.14598.ae

Witteles RM, Straus II FH, Sugg SL, Koka MR, Costa EA, Kaplan EL. Adult-onset nesidioblastosis causing hypoglycemia: an important clinical en¬tity and continuing treatment dilemma. Arch Surg. 2001; 136(6): 656- 663. doi: https://doi.org/10.1001/archsurg.136.6.656 (último acceso jul. 2024). DOI: https://doi.org/10.1001/archsurg.136.6.656

Published

2024-08-26

How to Cite

1.
Fernández-Riesgo M, Ena J, Sellés I, Abellán-Ponce R, Domínguez-Escribano JR. Endogenous hyperinsulinemic hypoglycemia as a case report: noninsulinoma pancreatogenic hypoglycemia syndrome (NIPHS). Rev Esp Casos Clin Med Intern [Internet]. 2024 Aug. 26 [cited 2024 Sep. 1];9(2):82-4. Available from: https://www.reccmi.com/RECCMI/article/view/984