Unrelated upper gastrointestinal haemorrhage as a debut of systemic amyloidosis
DOI:
https://doi.org/10.32818/reccmi.a2n1a3Keywords:
primary amyloidosis, gastrointestinal haemorrhage, amyloid substance, Red Congo, gastric mucosaAbstract
Amyloidosis AL is a rare disorder; the accumulation of a sufficient amount of amyloid material causes functional deterioration of the tissue in which it is deposited so the clinical presentation can be very diverse. We present a case with gastrointestinal involvement as a form of presentation within the systemic involvement of this entity; Demonstrating the amyloid deposit in the gastric biopsy. Gastrointestinal involvement is infrequent, and digestive haemorrhage may be the form of presentation, occasioned by lesions of the ulcer-like mucosa in the context of the capillary fragility underlying this pathology.
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Cowan AJ, Skinner M, Seldin DC, Berk JL, Lichtenstein DR, O’Hara CJ, et al. Amyloidosis of the gastrointestinal tract: a 13-year, singlecenter, referral experience. Haematologica. 2013; 98:141.
Waleed M, Ali AM, Saraj O, Babu S, Morgan R. A rare cause of lower GI bleeding. BMJ Case Reports. 2012. doi: https://doi.org/10.1136/bcr03.2012.6086.
James DG, Zuckerman GR, Sayuk GS, et al. Clinical recognition of AL type amyloidosis of the luminal gastrointestinal tract. Clinic Gastroenterol Hepatol. 2007; 5: 582-588.
Ko CW, Chow WK, Chang CS, et al. Endoscopic appearance of amyloidosis with gastrointestinal tract involvement after biopsy. Gastrointest Endosc. 1997; 46: 284-286.
Pramod KG, Vivek N. Iyer: An Usual Case of Lower Gastrointestinal bleeding. Am J Case Rep. 2016; 17: 170-172.
Madsen IG, Gimsing P, Schodt FV. Primary (AL) amyloidosis with gastrointestinal involvement. Scand J Gastroenterol. 2009; 44: 708-711.
Ali MF, Patel A, Muller S, Friedel D. Rare presentation of primary (AL) amyloidosis as gastrointestinal hemorrhage without systemic involvement. World J Gastrointest Endosc. 2014; 6: 144-147.
Wechalekar AD, Schonland SO, Kastritis E, Gillmore JD, Dimopoulos MA, Lane T, et al. A European collaborative study of treatment outcomes in 346 patients with cardiac stage III AL amyloidosis. Blood. 2013; 121: 3420-3427.
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Copyright (c) 2017 María Rocío Pacheco-Yepes, Iván Pérez-de Pedro, Beatriz Rivas-Sánchez, Estibaliz Romero-Masa, Ricardo Gómez-Huelgas
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