Sensorimotor polyneuropathy and bilateral optic neuropathy as a paraneoplastic syndrome secondary to the presence of anti-CV2/CRMP5 antibodies

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DOI:

https://doi.org/10.32818/reccmi.a7n3a8

Keywords:

paraneoplastic polyneuropathy, optic nerve diseases, anti-CRMP5 autoantibody

Abstract

We present the case of a 66-year-old patient with no relevant clinical conditions admitted into the Neurology de- partment with subacute gait disturbance and blurry vision. Fundus examination shows bilateral papilledema. Elec- troneurography discovers a sensorimotor polyneuropathy with axonal predominance. The image study shows a left lung mass with pathological diagnosis of cancer. The serum anti-neuronal antibodies are positive to anti-CV2 (co- llapsin response mediator protein [CRMP5]). The patient’s diagnosis is distal symmetric sensorimotor polyneuropathy and bilateral anterior optic neuropathy, both of paraneoplastic origin from a small cell lung carcinoma.

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References

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Published

2022-12-28

How to Cite

1.
Lobato-Martínez E, Moreno-Navarro L. Sensorimotor polyneuropathy and bilateral optic neuropathy as a paraneoplastic syndrome secondary to the presence of anti-CV2/CRMP5 antibodies. Rev Esp Casos Clin Med Intern [Internet]. 2022 Dec. 28 [cited 2024 Dec. 4];7(3):25-7. Available from: https://www.reccmi.com/RECCMI/article/view/796