Lymphocytic and granulomatous interstitial lung disease (GLILD) associated with common variable immunodeficiency

Authors

  • Juan Martínez-Andrés Internal Medicine Department, Hospital Can Misses, Ibiza (Islas Baleares), Spain
  • Patrick Teixeira de Sousa-dos Santos Internal Medicine Department, Hospital Can Misses, Ibiza (Islas Baleares), Spain
  • Irene Ferrando-Fabra Primary Health Care, Centro de Salud Can Misses, Ibiza (Islas Baleares), Spain
  • Ramón Leopoldo Canet Internal Medicine Department, Hospital Can Misses, Ibiza (Islas Baleares), Spain

DOI:

https://doi.org/10.32818/reccmi.a7n3a5

Keywords:

granulomatous-lymphocytic interstitial lung disease, common variable immunodeficiency

Abstract

Common variable immunodeficiency presents complications with its evolution, mainly of an infectious profile; lymphocytic and granulomatous interstitial lung disease is a lesser-known entity that primarily affect the lungs. The most recent evidence indicates that combined immunosuppressive treatments are the ones that achieve the most significant clinical improvement. We present the case of a patient with a long-standing cough who was finally diagnosed with lymphocytic and granulomatous interstitial lung disease and its evolution with the proposed treatment.

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References

Park JH, Levinson AI. Granulomatous-lymphocytic interstitial lung disease (GLILD) in common variable immunodeficiency (CVID). Clin Immunol. 2010; 134(2): 97-103. doi: https://doi.org/10.1016/j.clim.2009.10.002 DOI: https://doi.org/10.1016/j.clim.2009.10.002

Marciszewska E, Szaflarska A, Pituch-Noworolska A. Granulomatous lymphocytic interstitial lung disease (GLILD) as a manifestation of pulmonary changes in common variable immunodeficiency (CVID) – case report. Przegl Lek. 2016; 73(7): 530-3

Verbsky JW, Hintermeyer MK, Simpson PM, Feng M, Barbeau J, Rao N et al. Rituximab and antimetabolite treatment of granulomatous and lymphocytic interstitial lung disease in common variable immunodeficiency. J Allergy Clin Immunol. 2021; 147(2): 704-712.e17. doi: https://doi.org/10.1016/j.jaci.2020.07.021 DOI: https://doi.org/10.1016/j.jaci.2020.07.021

Lamers OAC, Smits BM, Leavis HL, de Bree GJ, Cunningham-Rundles C, Dalm VASH et al. Treatment Strategies for GLILD in Common Variable Immunodeficiency: A Systematic Review. Front Immunol. 2021; 12: 606099. doi: https://doi.org/10.3389/fimmu.2021.606099 DOI: https://doi.org/10.3389/fimmu.2021.606099

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Published

2022-12-28

How to Cite

1.
Martínez-Andrés J, Teixeira de Sousa-dos Santos P, Ferrando-Fabra I, Canet RL. Lymphocytic and granulomatous interstitial lung disease (GLILD) associated with common variable immunodeficiency. Rev Esp Casos Clin Med Intern [Internet]. 2022 Dec. 28 [cited 2024 Nov. 21];7(3):13-6. Available from: https://www.reccmi.com/RECCMI/article/view/774

Issue

Vol. 7 No. 3 (2022): Spanish Journal of Clinical Cases in Internal Medicine

Section

CLINICAL CASES

License

Copyright (c) 2022 Juan Martínez-Andrés, Patrick Teixeira de Sousa-dos Santos, Irene Ferrando-Fabra, Ramón Leopoldo Canet

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