Spinal cord compression as a debut of myeloid sarcoma with extensive bone involvement

Authors

  • Luis Francisco Caballero-Martínez Internal Medicine Department, Hospital Regional Universitario de Málaga, Málaga, Spain.
  • Clara Costo-Muriel Internal Medicine Department, Hospital Regional Universitario de Málaga, Málaga, Spain.
  • Jaime Sanz-Cánovas Internal Medicine Department, Hospital Regional Universitario de Málaga; Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain. https://orcid.org/0000-0003-3722-5492
  • Lidia Cobos-Palacios Internal Medicine Department, Hospital Regional Universitario de Málaga; Instituto de Investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain. https://orcid.org/0000-0003-4401-233X
  • Ricardo Gómez-Huelgas Internal Medicine Department, Hospital Regional Universitario de Málaga; Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, Málaga, Spain.

DOI:

https://doi.org/10.32818/reccmi.a7n2a2

Keywords:

myeloid sarcoma, spinal cord compression, hematologic neoplasms, spinal cord neoplasms

Abstract

Myeloid sarcoma is an extramedullary tumor usually found in patients with previous hematological neoplasms, with symptoms depending on the location of the lesions due to their mass effect. The main locations are lymph nodes and the skin. It requires a high clinical suspicion for its diagnosis and has a poor prognosis in the short-medium term.

We present a clinical case of a 64-year-old man with no hematological history who consulted for bone pain and spinal cord compression, observing extensive bone involvement on MRI and PET-TC. He suffered a nosocomial infectious complication and died in the ICU awaiting histological diagnostic confirmation.

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References

Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011; 117(19): 5019-32. doi: https://doi.org/10.1182/blood-2011-01-293050.

Wilson CS, Medeiros LJ. Extramedullary Manifestations of Myeloid Neoplasms. Am J Clin Pathol. 2015; 144(2): 219-39. doi: https://doi.org/10.1309/AJCPO58YWIBUBESX.

Campidelli C, Agostinelli C, Stitson R, Pileri SA. Myeloid sarcoma: extramedullary manifestation of myeloid disorders. Am J Clin Pathol. 2009; 132(3): 426-37. doi: https://doi.org/10.1309/AJCP1ZA7HYZKAZHS.

Magdy M, Abdel Karim N, Eldessouki I, Gaber O, Rahouma M, Ghareeb M. Myeloid Sarcoma. Oncol Res Treat. 2019; 42(4): 224-229. doi: https://doi.org/10.1159/000497210.

Aboutalebi A, Korman JB, Sohani AR, Hasserjian RP, Louissaint A Jr, Le L, Kraft S, Duncan LM, Nazarian RM. Aleukemic cutaneous myeloid sarcoma. J Cutan Pathol. 2013; 40(12): 996-1005. doi: https://doi.org/10.1111/cup.12231.

Seifert RP, Bulkeley W 3rd, Zhang L, Menes M, Bui MM. A practical approach to diagnose soft tissue myeloid sarcoma preceding or coinciding with acute myeloid leukemia. Ann Diagn Pathol. 2014; 18(4): 253-60. doi: https://doi.org/10.1016/j.anndiagpath.2014.06.001.

Traweek ST, Arber DA, Rappaport H, Brynes RK. Extramedullary myeloid cell tumors. An immunohistochemical and morphologic study of 28 cases. Am J Surg Pathol. 1993; 17(10): 1011-9. doi: https://doi.org/10.1097/00000478-199310000-00006.

Almond LM, Charalampakis M, Ford SJ, Gourevitch D, Desai A. Myeloid Sarcoma: Presentation, Diagnosis, and Treatment. Clin Lymphoma Myeloma Leuk. 2017; 17(5): 263-267. doi: https://doi.org/10.1016/j.clml.2017.02.027.

Begna KH, Kittur J, Yui J, Gangat N, Patnaik MM, Al-Kali A et al. De novo isolated myeloid sarcoma: comparative analysis of survival in 19 consecutive cases. Br J Haematol. 2021; 195(3): 413-416. doi: https://doi.org/10.1111/bjh.17742.

Published

2022-08-30

How to Cite

1.
Caballero-Martínez LF, Costo-Muriel C, Sanz-Cánovas J, Cobos-Palacios L, Gómez-Huelgas R. Spinal cord compression as a debut of myeloid sarcoma with extensive bone involvement. Rev Esp Casos Clin Med Intern [Internet]. 2022 Aug. 30 [cited 2024 Nov. 22];7(2):3-5. Available from: https://www.reccmi.com/RECCMI/article/view/651

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