Non-secretory myeloma

Authors

  • Jesús Ballano-Rodríguez-Solís Servicio de Medicina Interna. Hospital Universitario del Henares. Madrid. España
  • Itziar Carmona-Zabala Servicio de Hematología y Hemoterapia. Hospital Universitario del Henares, Coslada. Madrid. España
  • Santiago Nieto-Llanos Servicio de Anatomía Patológica. Hospital Universitario del Henares, Coslada. Madrid. España
  • Jaime de Miguel-Criado Servicio de Radiodiagnóstico. Hospital Universitario del Henares, Coslada. Madrid. España

DOI:

https://doi.org/10.32818/reccmi.a5n3a10

Keywords:

non-secretory myeloma, bone pain, vertebral compression fractures, secondary osteoporosis, leukoerythroblastic reaction.

Abstract

A non-secretory myeloma is an exceptional form of myeloma (1% of cases). It is a subtype that does not present mono-clonal gammopathy in serum or urine. The study of free light chains in serum is also negative. Bone fragility and bone pain, mainly if associated with anemia, hypercalcemia, and kidney failure, suggest its presence. We present a 76-year-old woman with vertebral compression fractures and diffuse bone pain, finally diagnosed with advanced non-secretory myeloma. This case intends to raise awareness about a rare entity to make an early diagnosis and treatment.

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References

Dupuis MM, Tuchman SA. Non-secretory multiple myeloma: from biology to clinical management. Onco Targets Ther. 2016; 9: 7583-7590. doi: https://doi.org/10.2147/OTT.S122241.

Corso A, Mangiacavalli S. Non-Secretory Myeloma: Ready for a new Defi- nition? Mediterr J Hematol Infect Dis. 2017; 9(1): e2017053. doi: https://doi.org/10.4084/MJHID.2017.053.

Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, et al. International Myeloma Working Group updated criteria for the diagno- sis of multiple myeloma. Lancet Oncol. 2014; 15(12): e538-48. doi: https://doi.org/10.1016/S1470-2045(14)70442-5.

Tabares Calvache E, Tabares Calvache AD, Faulhaber GAM. Systematic review about etiologic association to the leukoerythroblastic reaction. Int J Lab Hematol. 2020 Jun 20. doi: https://doi.org/10.1111/ijlh.13238.

Mosebach J, Thierjung H, Schlemmer HP, Delorme S. Multiple Myeloma Guidelines and Their Recent Updates: Implications for Imaging. Rofo. 2019; 191(11): 998-1009. doi: https://doi.org/10.1055/a-0897-3966.

Published

2020-12-31

How to Cite

1.
Ballano-Rodríguez-Solís J, Carmona-Zabala I, Nieto-Llanos S, de Miguel-Criado J. Non-secretory myeloma. Rev Esp Casos Clin Med Intern [Internet]. 2020 Dec. 31 [cited 2024 Dec. 22];5(3):126-8. Available from: https://www.reccmi.com/RECCMI/article/view/583