Non-secretory myeloma
DOI:
https://doi.org/10.32818/reccmi.a5n3a10Keywords:
non-secretory myeloma, bone pain, vertebral compression fractures, secondary osteoporosis, leukoerythroblastic reaction.Abstract
A non-secretory myeloma is an exceptional form of myeloma (1% of cases). It is a subtype that does not present mono-clonal gammopathy in serum or urine. The study of free light chains in serum is also negative. Bone fragility and bone pain, mainly if associated with anemia, hypercalcemia, and kidney failure, suggest its presence. We present a 76-year-old woman with vertebral compression fractures and diffuse bone pain, finally diagnosed with advanced non-secretory myeloma. This case intends to raise awareness about a rare entity to make an early diagnosis and treatment.
Downloads
Metrics
References
Dupuis MM, Tuchman SA. Non-secretory multiple myeloma: from biology to clinical management. Onco Targets Ther. 2016; 9: 7583-7590. doi: https://doi.org/10.2147/OTT.S122241.
Corso A, Mangiacavalli S. Non-Secretory Myeloma: Ready for a new Defi- nition? Mediterr J Hematol Infect Dis. 2017; 9(1): e2017053. doi: https://doi.org/10.4084/MJHID.2017.053.
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, et al. International Myeloma Working Group updated criteria for the diagno- sis of multiple myeloma. Lancet Oncol. 2014; 15(12): e538-48. doi: https://doi.org/10.1016/S1470-2045(14)70442-5.
Tabares Calvache E, Tabares Calvache AD, Faulhaber GAM. Systematic review about etiologic association to the leukoerythroblastic reaction. Int J Lab Hematol. 2020 Jun 20. doi: https://doi.org/10.1111/ijlh.13238.
Mosebach J, Thierjung H, Schlemmer HP, Delorme S. Multiple Myeloma Guidelines and Their Recent Updates: Implications for Imaging. Rofo. 2019; 191(11): 998-1009. doi: https://doi.org/10.1055/a-0897-3966.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Jesús Ballano-Rodríguez-Solís, Itziar Carmona-Zabala, Santiago Nieto-Llanos, Jaime de Miguel-Criado
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Permite compartir, copiar y redistribuir el material en cualquier medio o formato, bajo los siguientes términos:
Reconocimiento: debe otorgar el crédito correspondiente, proporcionar un enlace a la licencia e indicar si se realizaron cambios. Puede hacerlo de cualquier manera razonable, pero no de ninguna manera que sugiera que el licenciante lo respalda a usted o su uso.
No comercial: no puede utilizar el material con fines comerciales.
No Derivados: si remezcla, transforma o construye sobre el material, no puede distribuir el material modificado.
Sin restricciones adicionales: no puede aplicar términos legales o medidas tecnológicas que restrinjan legalmente a otros de hacer cualquier cosa que permita la licencia.