DRESS syndrome in a patient treated with sulfasalazine and amoxicillin-clavulanic acid

Authors

  • Rita Nogueiras-Álvarez Servicio de Farmacología Clínica. Hospital Universitario Marqués de Valdecilla. Santander. Cantabria. España
  • Aurora Gutiérrez-González Servicio de Alergología. Hospital El Bierzo. Ponferrada. León. España
  • Estefanía Alejandra Montenegro-Echeverría Servicio de Alergología. Hospital Universitario Marqués de Valdecilla. Santander. Cantabria. España
  • Ana María Arnáiz-García Servicio de Medicina Interna. Hospital Universitario Marqués de Valdecilla. Santander. Cantabria. España

DOI:

https://doi.org/10.32818/reccmi.a5n3a11

Keywords:

dress syndrome, drug hypersensitivity syndrome, drug reaction, clinical pharmacology, allergology.

Abstract

DRESS syndrome (Drug Rash with Eosinophilia and Systemic Symptoms) is a drug-induced hypersensitivity syndrome that occurs between 2-6 weeks after the first taking of the responsible drug. We describe the case of a 57-year-old man who was admitted to our hospital due to a respiratory infection and a skin rash that was placed in the context of a DRESS syndrome. The cutaneous manifestations worsened after the intake of amoxicillin during concomitant treatment with sulfasalazine. When DRESS syndrome is suspected, withdrawal of the responsible drugs is crucial to avoid a possible fatal outcome.

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References

Kliegman RM, Stanton BM, St Geme J, Schor NF. Nelson Textbook of Pediatrics. 20th edition. Philadelphia, PA: Elsevier; 2016:3112-3113.

Sharifzadeh S, Mohammadpour AH, Tavanaee A, Elyasi S. Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review. Eur J Clin Pharmacol. 2020 Oct 6:1– 15. doi: https://doi.org/10.1007/s00228-020-03005-9.

Vatel O, Aumont C, Mathy V, Petit M, Feriel J, Sloma I, et al. Drug reaction with eosinophilia and systemic symptoms (DRESS) induced by imatinib in chronic myeloid leukemia. Leuk Lymphoma. 2017; 58(2): 473-74. doi: https://doi.org/10.1080/10428194.2016.1201575.

Fernando SL. Drug-reaction eosinophilia and systemic symptoms and drug-induced hypersensitivity syndrome. Australas J Dermatol. 2014; 55(1): 15-23. doi: https://doi.org/10.1111/ajd.12085.

Cacoub P, Musette P, Descamps V, Meyer O, Speirs C, Finzi L, et al. The DRESS syndrome: a literature review. Am J Med. 2011 Jul;124(7):588-97. doi: https://doi.org/10.1016/j.amjmed.2011.01.017.

Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler WJ. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol. 1995; 155(1): 462-72.

Kano Y, Hiraharas K, Sakuma K, Shiohara T. Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graftversus-host disease. Br J Dermatol. 2006; 155(2): 301-6. doi: https://doi.org/10.1111/j.1365-2133.2006.07238.x.

The RegiSCAR Project website: http://www.regiscar.org.

Chen Y-C, Cho Y-T, Chang C-Y, Chu C-Y. Drug reaction with eosinophilia and systemic symptoms: A drug-induced hypersensitivity syndrome with variable clinical features. Dermatol Sin. 2013; 31(4): 196-204. https://doi.org/10.1016/j.dsi.2013.09.006.

Sussman S, Devlin V, Dimitriades VR. A Teenager With Sulfasalazine- Associated DRESS Syndrome After the Introduction of Amoxicillin. Clin Pe- diatr (Phila). 2017; 56(3): 290-91. doi: https://doi.org/10.1177/0009922816656624.

Girelli F, Bernardi S, Gardelli L, Bassi B, Parente G, Dubini A, et al. A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin. Case Rep Rheumatol. 2013; 2013: 409152. doi: https://doi.org/10.1155/2013/409152.

Takimoto R, Honda T, Kataoka TR, Ueshima C, Otsuka A, Kabashima K. DIHS/ DRESS-like eruption possibly induced by amoxicillin during treatment with ni- volumab. Eur J Dermatol. 2019 Apr 1;29(2):228-229. doi: https://doi.org/10.1684/ejd.2019.3522.

Ben Fredj N, Aouam K, Chaabane A, Toumi A, Ben Rhomdhane F, Boughattas N, et al. Hypersensitivity to amoxicillin after drug rash with eosinophilia and systemic symptoms (DRESS) to carbamazepine and allopurinol: a possible co-sensitization. Br J Clin Pharmacol. 2010; 70(2): 273-6. doi: https://doi.org/10.1111/j.1365-2125.2010.03685.x.

Aouam K, Fredj Nadia B, Amel C, Naceur B. Amoxicillin-Induced Hyper- sensitivity After DRESS To Carbamazepine. World Allergy Organ J. 2010 Jul;3(7):220-2. doi: https://doi.org/10.1097/WOX.0b013e3181eab930.

Lang M, Fish J, Covelli C, Schreiber BE. DRESS syndrome triple whammy: sulfasalazine, amoxicillin and HHV-7. Br J Hosp Med (Lond). 2017; 78(11): 648-49. doi: https://doi.org/10.12968/hmed.2017.78.11.648.

Published

2020-12-31

How to Cite

1.
Nogueiras-Álvarez R, Gutiérrez-González A, Montenegro-Echeverría EA, Arnáiz-García AM. DRESS syndrome in a patient treated with sulfasalazine and amoxicillin-clavulanic acid. Rev Esp Casos Clin Med Intern [Internet]. 2020 Dec. 31 [cited 2024 Dec. 22];5(3):129-32. Available from: https://www.reccmi.com/RECCMI/article/view/562

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