Gastric hepatoid adenocarcinoma, producer of alphafetoprotein

Authors

  • Estefanía Aparicio-Castaño Unidad Docente de Medicina de Atención Familiar y Comunitaria de Cuenca. Cuenca. España
  • Montserrat Pérez-Pinar Servicio de Medicina Interna. Hospital Virgen de la Luz. Cuenca. España https://orcid.org/0000-0002-3683-5478
  • José Antonio Nieto-Rodríguez Servicio de Medicina Interna. Hospital Virgen de la Luz. Cuenca. España
  • Raquel Acedo-Mayordomo Unidad de Anatomía Patológica. Hospital Virgen de la Luz. Cuenca. España
  • Juan Carlos Palomo-Sánchez Servicio de Cirugía General. Hospital Virgen de la Luz. Cuenca. España

DOI:

https://doi.org/10.32818/reccmi.a5n2a3

Keywords:

gastric hepatoid adenocarcinoma, alpha fetoprotein, late diagnosis, metastatic, palliative treatment.

Abstract

Gastric hepatoid adenocarcinoma is a rare form of gastric cancer with a high mortality rate in the short-term. This is usually due to late diagnosis, which is accomplished in the last phases of the disease; the confirmation diagnosis needs not commons pathological techniques. Almost 64% produce alpha-fetoprotein and its morphology is similar to hepatocellular carcinoma. Early diagnosis and treatment are essential to increase survival.
We present a case about a metastatic gastric hepatoid adenocarcinoma in a healthy male, without risk factors of gastric cancer or hepatocellular carcinoma. This case aims to help other physicians to recognize their symptoms to get an earlier diagnosis and to improve its prognosis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

- Chen EB, Wei YC, Liu HN, Tang C, Liu ML, Peng K et al. Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer. Biomed Res Int. 2019; 2019: 6710428. doi: https://doi.org/10.1155/2019/6710428.

- Søreide JA. Therapeutic Approaches to Gastric Hepatoid Adenocarcinoma: Current Perspectives. Ther Clin Risk Manag. 2019; 15: 1469-1477. doi: https://doi.org/10.2147/TCRM.S204303.

- Søreide JA, Greve OJ, Gudlaugsson E, Størset S. Hepatoid adenocarcinoma of the stomach – proper identification and treatment remain a challenge, Scand J Gastroenterol. 2016; 51(6): 646-653. doi: https://doi.org/10.3109/00365521.2015.1124286.

- Fakhruddin N, Bahmad HF, Aridi T, et al. Hepatoid Adenocarcinoma of the Stomach: A Challenging Diagnosis and Therapeutic Disease through a Case Report and Review of the Literature. Front Med (Lausanne). 2017; 4: 164. doi: https://doi.org/10.3389/fmed.2017.00164.

- Becq A, Mateescu C, Khayat D, Bouattour M. Atypical Presentation of Hepatocellular Carcinoma Mimicking a Gastric Hepatoid Adenocarcinoma: A Case Report. Medicine (Baltimore). 2015; 94(27): e1101. doi: https://doi.org/10.1097/MD.0000000000001101.

–Xiao C, Wu F, Jiang H, Teng L, Song F, Wang Q et al. Hepatoid adenocarcinoma of the stomach: Nine case reports and treatment outcomes. Oncol Lett. 2015; 10(3): 1605-1609. doi: https://doi.org/10.3892/ol.2015.3430.

- Kuroda N, Yorita K. Clinicopathologic study of 10 cases of gastric adenocarcinoma with hepatoid or enteroblactic differentiation. Pol J Pathol. 2018; 69(2): 128-135. doi: https://doi.org/10.5114/pjp.2018.76696.

- Sun N, Sun Q, Liu Q, Zhang T, Zhu Q, Wang W et al. α-fetoprotein-producing gastric carcinoma: A case report of a rare subtype and literature review. Oncol Lett. 2016 May;11(5):3101-3104. doi: https://doi.org/10.3892/ol.2016.4372.

Published

2020-08-31

How to Cite

1.
Aparicio-Castaño E, Pérez-Pinar M, Nieto-Rodríguez JA, Acedo-Mayordomo R, Palomo-Sánchez JC. Gastric hepatoid adenocarcinoma, producer of alphafetoprotein. Rev Esp Casos Clin Med Intern [Internet]. 2020 Aug. 31 [cited 2024 Jul. 22];5(2):62-4. Available from: https://www.reccmi.com/RECCMI/article/view/487