There are no innocent drugs: hepatocellular damage induced by desloratadine
DOI:
https://doi.org/10.32818/reccmi.a4n3a4Keywords:
drug induced liver injury, desloratadine, hepatotoxicity, RUCAMAbstract
The symptoms, signs and alterations of liver function induced by drugs can mimic any type of liver disease. A case of hepatocellular lesion due to desloratadine is presented. Desloratadine is a drug metabolized by the liver via cytochrome P450 (CYP 3A4 and 2D6), with little reference in the literature as a cause of liver damage. The importance of monitoring liver function in patients treated with drugs with hepatotoxic potential is emphasized.
Downloads
Metrics
References
Andrade RJ, Lucena MI, Fernández MC, Peláez G, Pachkoria K, García-Ruiz E, et al. Spanish Group for the Study of Drug-Induced Liver Disease. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005; 129(2): 512- 521. doi: https://doi.org/10.1016/j.gastro.2005.05.006.
Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 1981; 30(2): 239-245. doi: https://doi.org/10.1038/clpt.1981.154.
Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015; 17(1): E14. doi: https://doi.org/10.3390/ijms17010014.
Danan G, Benichou C. Causality assessment of adverse reactions to drugs-I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries. J Clin Epidemiol. 1993; 46(11): 1323-1330.
Website: LiverTox.nih.gov. Database Updated: 01 November 2018. Accesible en: https://livertox.nlm.nih.gov/loratadine_Desloratadine.htm.
Schiano TD, Bellary SV, Cassidy MJ, Thomas RM, Black M. Subfulminant liver failure and severe hepatotoxicity caused by loratadine use. Ann Intern Med. 1996; 125(9): 738-740.
Schöttker B, Dösch A, Kraemer DM. Severe hepatotoxicity after application of desloratadine and fluconazole. Acta Haematol. 2003; 110(1): 43-44. doi: https://doi.org/10.1159/000072415.
Pérez R, Rodrigo L, Pérez R, de Francisco R. Acute cholestasis related to desloratidine. World J Gastroenterol. 2005; 11(23): 3647-3648. doi: https://doi.org/10.3748/wjg.v11.i23.3647.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 María Dolores González-Vázquez, Marta Sofia Rafael-Marques, Susana Marques-de Sousa, Maria Alexandra Duarte, Ângela Daniela Coelho
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Permite compartir, copiar y redistribuir el material en cualquier medio o formato, bajo los siguientes términos:
Reconocimiento: debe otorgar el crédito correspondiente, proporcionar un enlace a la licencia e indicar si se realizaron cambios. Puede hacerlo de cualquier manera razonable, pero no de ninguna manera que sugiera que el licenciante lo respalda a usted o su uso.
No comercial: no puede utilizar el material con fines comerciales.
No Derivados: si remezcla, transforma o construye sobre el material, no puede distribuir el material modificado.
Sin restricciones adicionales: no puede aplicar términos legales o medidas tecnológicas que restrinjan legalmente a otros de hacer cualquier cosa que permita la licencia.
