Autoimmune necrotizing myositis and statin derma- tomyositis: a complex differential diagnosis

Authors

  • Enrique Mira-Bleda Servicio de Medicina Interna. Hospital Clínico Universitario Virgen de la Arrixaca. Murcia. España
  • Bartolomé García-Pérez Servicio de Medicina Interna. Hospital Clínico Universitario Virgen de la Arrixaca. Murcia. España
  • Ana Azahara García-Ortega Servicio de Radiología. Hospital Clínico Universitario Virgen de la Arrixaca. Murcia. España
  • Vladimir Salazar-Rosa Servicio de Medicina Interna. Hospital Clínico Universitario Virgen de la Arrixaca. Murcia. España
  • Enrique Bernal-Morell Servicio de Medicina Interna. Hospital Clínico Universitario Reina Sofía. Murcia. España
  • Laura Barona-García Servicio de Anatomía Patológica. Hospital Clínico Universitario Virgen de la Arrixaca. Murcia. España

DOI:

https://doi.org/10.32818/reccmi.a4n2a7

Keywords:

myositis, dermatomyositis, hydroxymethylglutaryl-coa Reductase Inhibitors

Abstract

Treatment with statins can induce muscle toxicity relatively frequently. With a lower incidence, statins can lead to an autoimmune necrotizing myopathy or dermatomyositis, myopathies which can potentially be severe with clinical, analytical and histological features. We present the case of a middle-aged woman who, after starting treatment with atorvastatin, presents an inflammatory myopathy, difficult to fit into a subtype, with skin lesions suggestive of dermatomyositis, however, histologically compatible with a necrotizing myopathy caused by statins.

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References

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Tiniakou E, Christopher-Stine L. Immune mediated necrotizing myopathy associated with statins: history and recent developments. Curr Opin Rheu- matol. 2017; 29(6): 604-611. doi: https://doi.org/10.1097/BOR.0000000000000438.

Chemello RML, Benvegnú AM, Dallazem LND, Chemello D. Aggressive and fatal statin induced dermatomyositis: a case report. Oxf Med Case Reports. 2017; 2017(12): omx063. doi: https://doi.org/10.1093/omcr/omx063.

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Published

2019-08-31

How to Cite

1.
Mira-Bleda E, García-Pérez B, García-Ortega AA, Salazar-Rosa V, Bernal-Morell E, Barona-García L. Autoimmune necrotizing myositis and statin derma- tomyositis: a complex differential diagnosis. Rev Esp Casos Clin Med Intern [Internet]. 2019 Aug. 31 [cited 2024 Dec. 22];4(2):61-3. Available from: https://www.reccmi.com/RECCMI/article/view/398