Management of the pregnant woman with obstetric and thrombotic antiphospholipid syndrome
DOI:
https://doi.org/10.32818/reccmi.a3n2a17Keywords:
antiphospholipid syndrome, pregnancy, anticoagulation, low molecular weight heparin, lupus anticoagulant.Abstract
Antiphospholipid syndrome is a systemic autoimmune disease in which the underlying pathological process described is the thrombosis in any vascular place and/or obstetric morbidity. Given the variability of its clinical symptoms we can speak of two variants of the same disease whose management is different in terms of follow-up and treatment. We present a case of a pregnancy in the context of a complete antiphospholipid syndrome (thrombotic and obstetric). The planning of pregnancy and childbirth, the close and coordinated follow-up, as well as the individualization of the treatment were essential to carry out the gestation.
Downloads
Metrics
References
Garcia D, Erkan D. Diagnosis and management of the antiphospholipid syndrome. N Engl J Med. 2018; 378: 2010-2021.
Alijotas-Reig J, Ferrer-Oliveras R, Ruffatti A, Tincani A, Lefkou E, Bertero MT, et al. (EUROAPS Study Group Collaborators). The European Registry on Obstetric Antiphospholipid Syndrome (EUROAPS): a survey of 247 consecutive cases. Autoimmun Rev. 2015; 14: 387-395.
Bramham K, Hunt BJ, Germain S, et al. Pregnancy outcome in different clinical phenotypes of antiphospholipid syndrome. Lupus. 2010; 19: 58-64.
Ruiz-Irastorza G, Khamashta MA. Lupus and pregnancy: ten questions and some answers. Lupus. 2008; 17: 416-420.
Branch DW, Khamashta MA. Antiphospholipid syndrome: obstetric diagnosis, management and controversies. Obstet Gynecol. 2003; 201: 1333-1344.
Bounameaux H, de Moerloose P. Is laboratory monitoring of low-molecular-wight heparin therapy necessary? No. J Thromb Haemost. 2004; 2: 551-554.
Trenfield S, Parmar K, Hunt B. Monitoring heparin in patients with a lupus anticoagulant: detection of heparin resisstance. J Thromb Haemost. 2008; 6: 1980-1982.
Thachil J. Should low molecular weiht heparin dosing be based on anti-Xa assays in antiphospholipid syndrome? Blood Coagul Fibryinolysis. 2013; 24: 82-84.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Eva Talavera-García , Emma Alarcón-Cuenca , Miriam Moreno-Conde , Juan Criado-García , María Gracia Cruz-Caparrós
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Permite compartir, copiar y redistribuir el material en cualquier medio o formato, bajo los siguientes términos:
Reconocimiento: debe otorgar el crédito correspondiente, proporcionar un enlace a la licencia e indicar si se realizaron cambios. Puede hacerlo de cualquier manera razonable, pero no de ninguna manera que sugiera que el licenciante lo respalda a usted o su uso.
No comercial: no puede utilizar el material con fines comerciales.
No Derivados: si remezcla, transforma o construye sobre el material, no puede distribuir el material modificado.
Sin restricciones adicionales: no puede aplicar términos legales o medidas tecnológicas que restrinjan legalmente a otros de hacer cualquier cosa que permita la licencia.