Double Cushing's

Authors

  • María Aguilera-García Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, Spain
  • Miguel Martínez-Martín Servicio de Medicina Interna, Hospital Universitario de La Princesa, Madrid, Spain

DOI:

https://doi.org/10.32818/reccmi.a2n2a13

Keywords:

Cushing's syndrome, ectopic, oat-cell lung carcinoma

Abstract

A 73 year-old male, ex-smoker, with hypertension, rheumatoid arthritis and associated interstitial lung disease. He is undergoing chronic treatment with prednisone and methotrexate. He starts study because of wasting syndrome, poor control of blood pressure, and the discovery of metabolic alkalosis and hypokalemia. In additional tests we find signs of increased mineralocorticoid activity but suppressed levels of aldosterone and plasma renin. In addition, we find hypercortisolism with biochemical confirmation of ectopic Cushing syndrome. In parallel, we reach the diagnosis of oat-cell lung carcinoma as the neoplasia that justifies the paraneoplasic syndrome.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Uptodate. Nieman LK. Epidemiology and clinical manifestations of Cushing’s syndrome. Jan 11, 2017. Uptodate Waltham, Massachusetts. Disponible en https://uptodate.com.

Guillín C, Bernabeu I, Rodríguez-Gómez IA, Casanueva FF. Hipercortisolismo de origen adrenal. Medicine-Programa de Formación Médica Continuada Acreditado. Editado por Elsevier. 2016;12(14):781-6. Accesible en https://www.medicineonline.es.

Loriaux DL. Diagnosis and Differential Diagnosis of Cushing’s Syndrome. N Engl J Med 2017; 376;15. 1451-1459.

Uptodate. Nieman LK. Causes and pathophysiology of Cushing’s syndrome. Feb 15, 2017. Uptodate Waltham, Massachusetts. Disponible en https://uptodate.com.

Stewart PM, Newell-Price JDC. The adrenal cortex. Williams Textbook of Endrocrinology. Thirteenth Edition. Chapter 15, 489-555.

Luque Ramírez M, Alpañés Buesa M, Álvarez Blasco F, Escobar Morreale HF. Hiperaldosteronismo primario y secundario. Medicine-Programa de Formación Médica Continuada Acreditado. Editado por Elsevier. 2012;11(15):871-82. Accesible en https://www.medicineonline.es

Blanco Carrera C, Fernández-Fernández C, Escribano Taioli P. Adenomas funcionantes de la hipófisis. Medicine-Programa de Formación Médica Continuada Acreditado. Editado por Elsevier. 2016;12(15):838-49. Accesible en https://www.medicineonline.es.

Published

2017-08-31

How to Cite

1.
Aguilera-García M, Martínez-Martín M. Double Cushing’s. Rev Esp Casos Clin Med Intern [Internet]. 2017 Aug. 31 [cited 2024 Dec. 21];2(2):97-9. Available from: https://www.reccmi.com/RECCMI/article/view/161