Blastic bone lesions, a rare presentation of systemic mastocytosis
DOI:
https://doi.org/10.32818/reccmi.a10n1a11Keywords:
bone marrow diseases, systemic mastocytosis, tryptases, bone marrow examinationAbstract
Systemic mastocytosis (SM), a rare myeloid neoplasm, is characterized by the pathological proliferation of mast cells in various organs. The most common symptoms include anaphylaxis, urticaria, abdominal pain, diarrhea, and depression. However, SM may also present with uncommon manifestations, such as osteosclerotic lesions. Diagnosis is based on elevated serum tryptase and specific bone marrow alterations according to the World Health Organization criteria. We present the case of a 38-year-old male with systemic mastocytosis, initially presenting with bone pain, polyclonal hypergammaglobulinemia, and osteosclerotic lesions. The diagnosis was confirmed through bone marrow biopsy, and the patient showed clinical improvement with sodium cromoglycate treatment.
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