Myopathy due to interaction of cyclosporine, atorvastatin and verapamil

Authors

DOI:

https://doi.org/10.32818/reccmi.a9n3a3

Keywords:

cyclosporine, atorvastatin, verapamil, myopathy

Abstract

It has been described a higher muscle toxicity when cyclosporine is used mixed with other drugs that interact with
enzymes from cytochrome P450 3A4 (CYP3A4), such as atorvastatin or verapamil. It is due to their shared metabolism
by these enzymes. A conscious prescription of drugs and keeping in mind that possible interactions may
occur, make it possible to avoid muscle destruction and acute renal failure risk. We introduce the case of a man
who developed myopathy due to treatment with cyclosporine, atorvastatin and verapamil.

A conscious prescription of drugs and keeping in mind that possible interactions may occur, make it possible to avoid muscle destruction and acute renal failure risk. 

We introduce the case of a man who developed myopathy due to treatment with cyclosporine, atorvastatin and verapamil

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References

Li S, Yu Y, Jin Z, Dai Y, Lin H, Jiao Z, et al. Prediction of pharmacokinetic drugdrug

interactions causing atorvastatin-induced rhabdomyolysis using physiologically

based pharmacokinetic modeling. Biomed Amp Pharmacother.

; 119: 109416. doi: https://doi.org/10.1016/j.biopha.2019.109416 (último DOI: https://doi.org/10.1016/j.biopha.2019.109416

acceso oct. 2024).

Yang Y, Li P, Zhang Z, Wang Z, Liu L, Liu X. Prediction of cyclosporin-mediated

drug interaction using physiologically based pharmacokinetic model

characterizing interplay of drug transporters and enzymes. Int J Mol Sci.

; 21(19): 7023. doi: https://doi.org/10.3390/ijms21197023 (último acceso DOI: https://doi.org/10.3390/ijms21197023

oct. 2024).

Asberg A, Hartmann A, Fjeldsa E, Bergan S, Holdaas H. Bilateral pharmacokinetic

interaction between cyclosporine A and atorvastatin in renal

transplant recipients. Am J Transplant. 2001; 1(4): 382-6. doi: https://doi.

org/10.1034/j.1600-6143.2001.10415.x (último acceso oct. 2024).

Compston A. Aids to the investigation of peripheral nerve injuries. Medical

Research Council: Nerve Injuries Research Committee. His Majesty's Stationery

Office: 1942; pp. 48 (iii) and 74 figures and 7 diagrams; with aids to the

examination of the peripheral nervous system. By Michael O'Brien for the

Guarantors of Brain. Saunders Elsevier: 2010; pp. [8] 64 and 94 Figures. Brain.

; 133(10): 2838-44. doi: https://doi.org/10.1093/brain/awq270 (último DOI: https://doi.org/10.1093/brain/awq270

acceso oct. 2024).

Lemahieu WP, Hermann M, Asberg A, Verbeke K, Holdaas H, Vanrenterghem

Y, et al. Combined Therapy with Atorvastatin and Calcineurin Inhibitors: No

Interactions with Tacrolimus. Am J Transplant. 2005; 5(9): 2236-43. https://

doi.org/10.1111/j.1600-6143.2005.01005.x (último acceso oct. 2024).

Sainz de Medrano Sainz JI, Brunet Serra M. Influencia de la farmacogenética

en la diversidad de respuesta a las estatinas asociada a las reacciones

adversas. Adv Lab Med. 2023; 4(4): 353-364. doi: https://doi.org/10.1515/

almed-2023-0064 (último acceso oct. 2024).

Franco D, Henao Y, Monsalve M, Gutiérrez F, Hincapie J, Amariles P. Interacciones

medicamentosas de agentes hipolipemiantes: Aproximación para

establecer y valorar su relevancia clínica. Revisión estructurada. Farm Hosp.

; 37(6): 539-557. https://doi.org/10.7399/FH.2013.37.6.1077 (último acceso

oct. 2024).

Frey FJ. Pharmacokinetic determinants of cyclosporine and prednisone in

renal transplant patients. Kidney Int. 1991; 39(5): 1034-50. doi: https://doi. DOI: https://doi.org/10.1038/ki.1991.131

org/10.1038/ki.1991.131 (último acceso oct. 2024).

Published

2024-12-31

How to Cite

1.
González-Angulo O, Aguilar-García JA, Fernández-Canedo MI. Myopathy due to interaction of cyclosporine, atorvastatin and verapamil. Rev Esp Casos Clin Med Intern [Internet]. 2024 Dec. 31 [cited 2025 Feb. 5];9(3):114-6. Available from: https://www.reccmi.com/RECCMI/article/view/979