Sensorimotor polyneuropathy and bilateral optic neuropathy as a paraneoplastic syndrome secondary to the presence of anti-CV2/CRMP5 antibodies

Authors

DOI:

https://doi.org/10.32818/reccmi.a7n3a8

Keywords:

paraneoplastic polyneuropathy, optic nerve diseases, anti-CRMP5 autoantibody

Abstract

We present the case of a 66-year-old patient with no relevant clinical conditions admitted into the Neurology de- partment with subacute gait disturbance and blurry vision. Fundus examination shows bilateral papilledema. Elec- troneurography discovers a sensorimotor polyneuropathy with axonal predominance. The image study shows a left lung mass with pathological diagnosis of cancer. The serum anti-neuronal antibodies are positive to anti-CV2 (co- llapsin response mediator protein [CRMP5]). The patient’s diagnosis is distal symmetric sensorimotor polyneuropathy and bilateral anterior optic neuropathy, both of paraneoplastic origin from a small cell lung carcinoma.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

References

Jáuregui A, Gutiérrez-Gutiérrez G, Bárcena J, González A, Gutiérrez-Rivas E. Enfermedades del sistema nervioso periférico. En: Zarranz JJ. Neurología, 6 ed. Barcelona: Elsevier; 2018. p. 583-624.

Neuropatía periférica. En: Berkowitz AL. Neurología clínica y Neuroanatomía, un enfoque basado en la localización, 1ed. Barcelona: McGraw Hill; 2020. p. 281-88.

El nervio óptico y su patología. En: Graue Wiechers E. Oftalmología en la práctica de la medicina general, 4ed. USA: McGraw Hill; 2014.

Gutiérrez-Gutiérrez G. Protocolo diagnóstico de polineuropatía. Medicine. Programa de Formación Médica Continuada Acreditado. 2015; 11 (78): 4720-23. Accesible en: https://www.sciencedirect.com/science/article/pii/S0304541215001006 (último acceso jul. 2022). DOI: https://doi.org/10.1016/j.med.2015.05.007

Edema de papila. En: Rebolleda-Fernández G, Muñoz-Negrete FJ. Protocolos en Neurooftalmología. Madrid: Sociedad Española de Oftalmología; 2010. p21-74. Accesible en: https://www.oftalmoseo.com/documentacion/MR2010/Capi%CC%81tulo_02%20Edema%20de%20papila%20-%20Papila%20elevada.pdf (último acceso jul. 2022).

Muppidi S, Vernino S. Paraneoplastic neuropathies. Continuum (Minneap Minn). 2014; 20(5 Peripheral Nervous System Disorders): 1359-72. Accesible en: https://journals.lww.com/continuum/Abstract/2014/10000/Paraneoplastic_Neuropathies.20.aspx (último acceso jul. 2022). DOI: https://doi.org/10.1212/01.CON.0000455876.53309.ec

Published

2022-12-28

How to Cite

1.
Lobato-Martínez E, Moreno-Navarro L. Sensorimotor polyneuropathy and bilateral optic neuropathy as a paraneoplastic syndrome secondary to the presence of anti-CV2/CRMP5 antibodies. Rev Esp Casos Clin Med Intern [Internet]. 2022 Dec. 28 [cited 2024 Dec. 26];7(3):25-7. Available from: https://www.reccmi.com/RECCMI/article/view/796