Generalized weakness: hyponatremia or myasthenia?

Authors

  • Marina García de Vicuña-Oyaga Internal Medicine Department, Valladolid University Clinical Hospital, Valladolid, Spain https://orcid.org/0009-0006-0042-6417
  • Sara Gómez-García Internal Medicine Department, Valladolid University Clinical Hospital, Valladolid, Spain https://orcid.org/0009-0005-7562-1244
  • Pablo Tellería-Gómez Internal Medicine Department, Valladolid University Clinical Hospital, Valladolid, Spain
  • Marta de la Fuente-López Internal Medicine Department, Valladolid University Clinical Hospital, Valladolid, Spain https://orcid.org/0009-0009-9437-7960
  • Miguel Martín-Asenjo Internal Medicine Department, Valladolid University Clinical Hospital, Valladolid, Spain https://orcid.org/0000-0001-8487-4490

DOI:

https://doi.org/10.32818/reccmi.a9s1a8

Keywords:

hyponatremia, SIADH, thymoma, myasthenia gravis, urea

Abstract

A 71-year-old woman came to the Emergency Department with asthenia and she was found to have moderate hyponatremia. The patient was admitted for correction and further evaluation, with an initial diagnosis of drug-induced SIADH. However, a chest CT scan revealed a mediastinal mass suggestive of thymic carcinoma. During the hospitalization, sodium correction was ineffective until oral urea was considered as a therapeutic option for treatment. She was discharged with a diagnosis of malignancy-associated SIADH, pending surgical evaluation. A few days later, the patient was admitted to Neurology, where her generalized weakness was diagnosed as myasthenia gravis associated with thymoma.

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References

Burst V. Etiology and epidemiology of hyponatremia. Front Horm Res. 2019; 52: 24-35. doi: https://doi.org/10.1159/000493234 (último acceso sept. 2024). DOI: https://doi.org/10.1159/000493234

Adrogué HJ, Tucker BM, Madias NE. Diagnosis and management of hyponatremia: a review. JAMA. 2022; 328(3): 280-291. doi: https://doi.org/10.1001/jama.2022.11176 (último acceso sept. 2024). DOI: https://doi.org/10.1001/jama.2022.11176

Warren AM, Grossmann M, Christ-Crain M, Russell N. Syndrome of inappropriate antidiuresis: from pathophysiology to management. Endocr Rev. 2023; 44(5): 819-861. doi: https://doi.org/10.1210/endrev/bnad010 (último acceso sept. 2024). DOI: https://doi.org/10.1210/endrev/bnad010

Adrogue HJ, Madias NE. Diagnosis and treatment of hyponatremia. Am J Kidney Dis. 2014; 64(5): 681-684. doi: https://doi.org/10.1053/j.ajkd.2014.06.001 (último acceso sept. 2024). DOI: https://doi.org/10.1053/j.ajkd.2014.06.001

Barajas Galindo DE, Ruiz-Sánchez JG, Fernández Martínez A, Runkle de la Vega I, Ferrer García JC, Ropero-Luis G, et al. Consensus document on the management of hyponatraemia of the Acqua Group of the Spanish Society of Endocrinology and Nutrition. Endocrinol Diabetes Nutr. 2023; 70(Suppl. 1): 7-26. doi: https://doi.org/10.1016/j.endien.2022.11.006 (último acceso sept. 2024). DOI: https://doi.org/10.1016/j.endien.2022.11.006

Rondon-Berrios H, Tandukar S, Mor MK, et al. Urea for the treatment of hyponatremia. Clin J Am Soc Nephrol. 2018; 13(11): 1627-1632. doi: https://doi.org/10.2215/CJN.04020318 (último acceso sept. 2024). DOI: https://doi.org/10.2215/CJN.04020318

Published

2024-11-30

How to Cite

1.
García de Vicuña-Oyaga M, Gómez-García S, Tellería-Gómez P, de la Fuente-López M, Martín-Asenjo M. Generalized weakness: hyponatremia or myasthenia? . Rev Esp Casos Clin Med Intern [Internet]. 2024 Nov. 30 [cited 2024 Dec. 26];9(Supl. 1):20-2. Available from: https://www.reccmi.com/RECCMI/article/view/1061