Multifactorial approach to long QT syndrome acquired in COVID-19
DOI:
https://doi.org/10.32818/reccmi.a5n2a13Keywords:
long QT syndrome, COVID-19.Abstract
The prolongation of the QT interval is a finding that is sometimes undervalued, but that can potentially lead to the development of arrhythmogenic processes. Many patients are being treated for COVID-19 with drugs that potentially prolong QT. This clinical case aims to demonstrate that the prevention of its appearance and the study of other concomitant alterations that favor it are essential in the comprehensive approach to these patients.
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Mercuro NJ, Yen CF, Shim DJ, Maher TR, McCoy CM, Zimetbaum PJ et al. Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing Positive for Coronavirus Disease 2019 (COVID-19). JAMA Cardiol. 2020; e201834. doi: https://doi.org/10.1001/jamacardio.2020.1834.
Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V et al; American Heart Association Acute Cardiac Care Committee of the Council on Clinical Cardiology; Council on Cardiovascular Nursing; American College of Cardiology Foundation. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010; 55(9): 934-47. doi: https://doi.org/10.1016/j.jacc.2010.01.001.
Capel RA, Herring N, Kalla M, Yavari A, Mirams GR, Douglas G et al. Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential. Heart Rhythm. 2015; 12(10): 2186-94. doi: https://doi.org/10.1016/j.hrthm.2015.05.027.
Lee JY, Vinayagamoorthy N, Han K, Kwok SK, Ju JH, Park KS et al. Association of Polymorphisms of Cytochrome P450 2D6 With Blood Hydroxychloroquine Levels in Patients With Systemic Lupus Erythematosus. Arthritis Rheumatol. 2016 Jan;68(1):184-90. doi: https://doi.org/10.1002/art.39402.
Chen CY, Wang FL, Lin CC. Chronic hydroxychloroquine use associated with QT prolongation and refractory ventricular arrhythmia. Clin Toxicol (Phila). 2006; 44(2): 173‐175. doi: https://doi.org/10.1080/15563650500514558.
Goldenberg I, Zareba W, Moss AJ. Long QT Syndrome. Curr Probl Cardiol. 2008; 33(11): 629‐694. doi: https://doi.org/10.1016/j.cpcardiol.2008.07.002.
Vandenberk B, Vandael E, Robyns T, Vandenberghe J, Garweg C, Foulon V et al. Which QT Correction Formulae to Use for QT Monitoring? J Am Heart Assoc. 2016; 5(6): e003264. doi: https://doi.org/10.1161/JAHA.116.003264.
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Copyright (c) 2020 Juan Mora-Delgado, Ana Del-Río-Lechuga, Cristina Lojo Cruz
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